BB1 regimen consists of 2 main herbal constituents (Eurycoma longifolia
J. and Polyscias fructicosa). Both plants were identified to exert
androgen activity and enhance sexual behavior on rats. This study aimed
to evaluate sexual protective effect of BB1 against sodium
valproate-induced hypogonadism in rats. The results showed that BB1 with
the dose of 0.47g/kg body weight significantly increased sperm density,
sperm motility, and rate of living sperm. On morphology of sperms, BB1
formulation increased percentage of normal morphology of sperm,
decreased percentage of abnormal in head and tail of sperm. In testes
histology, there was recovery development of germ cells from the base to
the center of the lumen; spermatogonia, primary and secondary
spermatocytes, spermatids, and spermatozoa were seen in the lumen of
testes of rats in BB1-treated group.
These results suggest that BB1 with the dose of 0.47g/kg body weight has
protective effects on sodium valproate- induced hypogonadism in rats.
| Title: | Đánh giá tác dụng của chế phẩm BB1 trên sự suy sinh dục gây ra bởi Natri Valproat |
| Authors: | Dương, Thị Ly Hương |
| Keywords: | BB1, Hypogonadism |
| Issue Date: | 2013 |
| Publisher: | Tạp chí Dược liệu |
| Abstract: | BB1
regimen consists of 2 main herbal constituents (Eurycoma longifolia J.
and Polyscias fructicosa). Both plants were identified to exert androgen
activity and enhance sexual behavior on rats. This study aimed to
evaluate sexual protective effect of BB1 against sodium
valproate-induced hypogonadism in rats. The results showed that BB1 with
the dose of 0.47g/kg body weight significantly increased sperm density,
sperm motility, and rate of living sperm. On morphology of sperms, BB1
formulation increased percentage of normal morphology of sperm,
decreased percentage of abnormal in head and tail of sperm. In testes
histology, there was recovery development of germ cells from the base to
the center of the lumen; spermatogonia, primary and secondary
spermatocytes, spermatids, and spermatozoa were seen in the lumen of
testes of rats in BB1-treated group.
These results suggest that BB1 with the dose of 0.47g/kg body weight has
protective effects on sodium valproate- induced hypogonadism in rats. |
| URI: | http://repository.vnu.edu.vn/handle/VNU_123/11516 |
| Appears in Collections: | SMP - Papers / Tham luận HN-HT |
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